Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain
Identifieur interne : 002225 ( Main/Exploration ); précédent : 002224; suivant : 002226Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain
Auteurs : A. N. Slepushkin [Russie] ; P. A. Patriarca [États-Unis] ; N. P. Obrosova-Serova [Russie] ; M. W. Harmon [États-Unis] ; L. N. Kupryashina [Russie] ; S. G. Cheshik [Russie] ; R. B. Vartanyan [Russie] ; G. I. Alexandrova [Russie] ; F. I. Polezhaev [Russie] ; N. I. Lonskaya [Russie] ; B. V. Yagodovskii [Russie] ; A. P. Kendal [États-Unis] ; V. M. Zhdanov [Russie]Source :
- Vaccine [ 0264-410X ] ; 1988.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (analyse), Enfant, Humains, Immunoglobuline A (immunologie), Immunoglobuline G (immunologie), Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Spécificité des anticorps, Tests d'inhibition de l'hémagglutination, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Anticorps antiviraux.
- génétique : Virus de la grippe A.
- immunologie : Immunoglobuline A, Immunoglobuline G, Vaccins antigrippaux, Virus de la grippe A.
- Enfant, Humains, Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Spécificité des anticorps, Tests d'inhibition de l'hémagglutination, Vaccination.
English descriptors
- KwdEn :
- Antibodies, Viral (analysis), Antibody Specificity, Child, Hemagglutination Inhibition Tests, Humans, Immunoglobulin A (immunology), Immunoglobulin G (immunology), Influenza A Virus, H1N1 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Recombination, Genetic, Vaccination.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- chemical , immunology : Immunoglobulin A, Immunoglobulin G, Influenza Vaccines.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- Teeft :
- Adequate infectivity, Antibody Specificity, Antibody responses, Antibody titres, Attenuated, Attenuated influenza vaccines, Attenuated paediatric influenza vaccine, Attenuated vaccine, Attenuated vaccines, Child, Disease control, Dos, Enzyme immunoassay, Experimental medicine, First vaccination, First vaccine dose, Hemagglutination Inhibition Tests, Human services, Humans, Immunoassay, Infectivity, Influenza, Influenza A Virus, H1N1 Subtype, Influenza vaccine strain, Influenza vaccines, Influenza virus vaccine, Kendal, Medical sciences, Monoclonal antibodies, Nasal secretions, Placebo, Placebo group, Production institute, Public health, Recombinant, Recombinant influenza virus, Recombination, Genetic, School children, School children vaccinated, Second dose, Second vaccination, Seroconversion rates, Vaccinated, Vaccinated children, Vaccination, Vaccine, Vaccine doses, Vaccine strain.
Abstract
Abstract: Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccinees and serum IgG antibody responses were detected in ≈40% by an enzyme immunoassay.
Url:
DOI: 10.1016/0264-410X(88)90009-6
Affiliations:
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N." last="Slepushkin">A. N. Slepushkin</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Academy of Medical Sciences of the USSR, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Patriarca, P A" sort="Patriarca, P A" uniqKey="Patriarca P" first="P. A." last="Patriarca">P. A. 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Zhdanov</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. 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Tests</term><term>Humans</term><term>Immunoglobulin A (immunology)</term><term>Immunoglobulin G (immunology)</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Recombination, Genetic</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (analyse)</term><term>Enfant</term><term>Humains</term><term>Immunoglobuline A (immunologie)</term><term>Immunoglobuline G (immunologie)</term><term>Recombinaison génétique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Spécificité des anticorps</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adequate infectivity</term><term>Antibody Specificity</term><term>Antibody responses</term><term>Antibody titres</term><term>Attenuated</term><term>Attenuated influenza vaccines</term><term>Attenuated paediatric influenza vaccine</term><term>Attenuated vaccine</term><term>Attenuated vaccines</term><term>Child</term><term>Disease control</term><term>Dos</term><term>Enzyme immunoassay</term><term>Experimental medicine</term><term>First vaccination</term><term>First vaccine dose</term><term>Hemagglutination Inhibition Tests</term><term>Human services</term><term>Humans</term><term>Immunoassay</term><term>Infectivity</term><term>Influenza</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza vaccine strain</term><term>Influenza vaccines</term><term>Influenza virus vaccine</term><term>Kendal</term><term>Medical sciences</term><term>Monoclonal antibodies</term><term>Nasal secretions</term><term>Placebo</term><term>Placebo group</term><term>Production institute</term><term>Public health</term><term>Recombinant</term><term>Recombinant influenza virus</term><term>Recombination, Genetic</term><term>School children</term><term>School children vaccinated</term><term>Second dose</term><term>Second vaccination</term><term>Seroconversion rates</term><term>Vaccinated</term><term>Vaccinated children</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine doses</term><term>Vaccine strain</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Humains</term><term>Recombinaison génétique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Spécificité des anticorps</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccinees and serum IgG antibody responses were detected in ≈40% by an enzyme immunoassay.</div></front></TEI><affiliations><list><country><li>Russie</li><li>États-Unis</li></country><region><li>District fédéral central</li><li>Géorgie (États-Unis)</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Slepushkin, A N" sort="Slepushkin, A N" uniqKey="Slepushkin A" first="A. N." last="Slepushkin">A. N. Slepushkin</name></region><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G. I." last="Alexandrova">G. I. Alexandrova</name><name sortKey="Cheshik, S G" sort="Cheshik, S G" uniqKey="Cheshik S" first="S. G." last="Cheshik">S. G. Cheshik</name><name sortKey="Kupryashina, L N" sort="Kupryashina, L N" uniqKey="Kupryashina L" first="L. N." last="Kupryashina">L. N. Kupryashina</name><name sortKey="Lonskaya, N I" sort="Lonskaya, N I" uniqKey="Lonskaya N" first="N. I." last="Lonskaya">N. I. Lonskaya</name><name sortKey="Obrosova Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N. P." last="Obrosova-Serova">N. P. Obrosova-Serova</name><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F. I." last="Polezhaev">F. I. Polezhaev</name><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F. I." last="Polezhaev">F. I. Polezhaev</name><name sortKey="Vartanyan, R B" sort="Vartanyan, R B" uniqKey="Vartanyan R" first="R. B." last="Vartanyan">R. B. Vartanyan</name><name sortKey="Yagodovskii, B V" sort="Yagodovskii, B V" uniqKey="Yagodovskii B" first="B. V." last="Yagodovskii">B. V. Yagodovskii</name><name sortKey="Zhdanov, V M" sort="Zhdanov, V M" uniqKey="Zhdanov V" first="V. M." last="Zhdanov">V. M. Zhdanov</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Patriarca, P A" sort="Patriarca, P A" uniqKey="Patriarca P" first="P. A." last="Patriarca">P. A. Patriarca</name></region><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M. W." last="Harmon">M. W. Harmon</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><name sortKey="Patriarca, P A" sort="Patriarca, P A" uniqKey="Patriarca P" first="P. A." last="Patriarca">P. A. Patriarca</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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